Honey is an old remedy recently rediscovered as a possible alternative to modern antibiotics in wound management but its mode of action is not fully understood. The antibacterial activity of honey can be divided into hydrogen peroxide and non-hydrogen peroxide-derived activity.
image credit: manukahoneyusa
See Prof. Rose Cooper, Professor of Microbiology, Cardiff School of Health Sciences, University of Wales Institute, Cardiff, explain on a recent BBC programme, how MEDIHONEY works in killing gram negative and gram positive organisms.
Electron microscopy showed that honey inflicted physical damages in both types of cells, and in Gram-positive bacteria led to an increase in the proportion of population of cells with a complete septum.
Gram-positive cells incubated in honey increased their endogenousre spiration rate whilst this was decreased in Gram-negative.
Major leakage was observed in Gram-negative bacteria whilst only minor leakage was observed in Gram-positive bacteria, which is consistent with the amount of damage observed with electron microscopy.